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KMID : 0389420120200040303
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Korean Journal of Stress Research
2012 Volume.20 No. 4 p.303 ~ p.308
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Association between Polymorphism of Oncostatin M Receptor and Obesity in Korean Population
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Yang Seung-Ae
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Abstract
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Oncostatin M receptor (OSMR) is responsible of signal transduction of oncostatin M (OSM) that might have associations with cancer, obesity, and type 2 diabetes, but few studies have examined this association in population. Our aim was to investigate that whether single nucleotide polymorphisms (SNPs) of the OSMR gene were associated with obesity in a Korean population. We genotyped 16 SNPs of the OSMR gene in 206 overweight/obesesubjects and 152 control subjects using the Affymetrix Targeted Genotyping chip array. One SNP (rs7709749) revealed association with overweight/obese subjects (p=0.029, log-additivemodel; p=0.042, recessive model). Furthermore, we examined the association between haplotypes built from 16 SNPs and overweight/obesity. The TC haplotype in block 2 (rs2367704 and rs647194) was also associated with overweight/obese (p=0.041). Our results suggest that the OSMR gene may be a possible risk factor in obesity.
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KEYWORD
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Association, Obesity, Oncostatin M receptor, Polymorphism
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